Human α-defensin 5

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Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC₅₀: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity.

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Human α-defensin 5 Chemical Structure

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Description	Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC₅₀: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity^[1].
Molecular Weight	3582.13
Formula	C₁₄₄H₂₃₈N₅₀O₄₅S₆
Sequence	Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-Cys-Ala-Thr-Arg-Glu-Ser-Leu-Ser-Gly-Val-Cys-Glu-Ile-Ser-Gly-Arg-Leu-Tyr-Arg-Leu-Cys-Cys-Arg (Disulfide bridge:Cys1-Cys6,Cys2-Cys4,Cys3-Cys5)
Sequence Shortening	ATCYCRTGRCATRESLSGVCEISGRLYRLCCR (Disulfide bridge:Cys1-Cys6,Cys2-Cys4,Cys3-Cys5)
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (260 KB) Handling Instructions (2659 KB)
References	[1]. Gounder AP, et al. Critical determinants of human α-defensin 5 activity against non-enveloped viruses. J Biol Chem. 2012 Jul 13;287(29):24554-62. [Content Brief] [2]. Tanaka T, et al. Parasiticidal activity of human alpha-defensin-5 against Toxoplasma gondii. In Vitro Cell Dev Biol Anim. 2010 Jun;46(6):560-5. [Content Brief]