2. Neuronal Signaling
  3. AAK1
  4. HW161023

HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC50 values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model.

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HW161023 Chemical Structure

HW161023 Chemical Structure

CAS No. : 2920698-73-1

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HW161023 Related Antibodies

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Description

HW161023 (compound 5) is an orally active AP2-associated protein kinase 1 (AAK1) inhibitor with IC50 values of 5.4 nM and 11.9 μM aganist of AAK1and hERG, respectively. HW161023 inhibits the pain in chronic constriction injury of the sciatic nerve rat model[1].

Molecular Weight

374.43

Formula

C20H24F2N4O
CAS No.
SMILES

CC(C)C[C@](C)(N)COC1=CC=C(C2=CC=NC(C(F)F)=C2)C3=NC=CN13
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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HW161023 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HW1610232920698-73-1HW 161023HW-161023AAK1Adaptor-associated Kinase 1AP2-associated kinase 1HepG 2 cellspain in chronic constriction injury of the sciatic nerve rat modelInhibitorinhibitorinhibit

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