2. PROTAC
  3. PROTAC Linkers
  4. Hydrazide-PEG4-Desthiobiotin

Hydrazide-PEG4-Desthiobiotin 

Cat. No.: HY-134722 Purity: ≥95.0%
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Hydrazide-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Hydrazide-PEG4-Desthiobiotin Chemical Structure

Hydrazide-PEG4-Desthiobiotin Chemical Structure

Size Price Stock Quantity
5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 520 In-stock
50 mg USD 820 In-stock
100 mg USD 1300 In-stock
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Based on 1 publication(s) in Google Scholar

Hydrazide-PEG4-Desthiobiotin Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

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Description

Hydrazide-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrazide-PEG4-Desthiobiotin Related Antibodies
Molecular Weight

475.58

Formula

C21H41N5O7
Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(NCCOCCOCCOCCOCCC(NN)=O)CCCCC[C@H]([C@H](C)N1)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Methanol : ≥ 125 mg/mL (262.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1027 mL 10.5135 mL 21.0270 mL
5 mM 0.4205 mL 2.1027 mL 4.2054 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.1027 mL 10.5135 mL 21.0270 mL 52.5674 mL
5 mM 0.4205 mL 2.1027 mL 4.2054 mL 10.5135 mL
10 mM 0.2103 mL 1.0513 mL 2.1027 mL 5.2567 mL
15 mM 0.1402 mL 0.7009 mL 1.4018 mL 3.5045 mL
20 mM 0.1051 mL 0.5257 mL 1.0513 mL 2.6284 mL
25 mM 0.0841 mL 0.4205 mL 0.8411 mL 2.1027 mL
30 mM 0.0701 mL 0.3504 mL 0.7009 mL 1.7522 mL
40 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.3142 mL
50 mM 0.0421 mL 0.2103 mL 0.4205 mL 1.0513 mL
60 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
80 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6571 mL
100 mM 0.0210 mL 0.1051 mL 0.2103 mL 0.5257 mL
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Hydrazide-PEG4-Desthiobiotin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrazide-PEG4-DesthiobiotinPROTAC LinkersInhibitorinhibitorinhibit

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