Hymeglusin  (Synonyms: F-244; 1233A; L-659699)

Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC₅₀ = 0.12 μM). Hymeglusin covalently modifies the active Cys¹²⁹ residue of the enzyme^[2][3].

IC50: 1.2 μM (HMG-CoA)^[2][3]

Hymeglusin inhibits dengue type 2 (DEN-2) New Guinea C (NGC) live virus replication in K562 cells. The therapeutic index (CC₅₀/IC₅₀) of Hymeglusin is 11. The EC₅₀ of Hymeglusin in K562 cells is 4.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

324.41

C₁₈H₂₈O₅

29066-42-0

Solid

White to off-white

O=C(O)/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@H]([C@H]1CO)OC1=O

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

• [1]. Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389(1-2):18-19.  [Content Brief]

  [2]. Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92.  [Content Brief]

  [3]. Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.  [Content Brief]