Hypeptin

Cat. No.: HY-P2223: FAQs
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Hypeptin is a cyclo-deposited peptide antibiotic produced by Lysobacter sp.K5869. Hypeptin blocks bacterial cell wall biosynthesis by binding to multiple undecaprenyl pyrophosphate-containing biosynthesis intermediates, forming a stoichiometric 2:1 complex. Hypeptin has antibacterial activity.

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Hypeptin Chemical Structure

CAS No. : 124883-38-1

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Description	Hypeptin is a cyclo-deposited peptide antibiotic produced by Lysobacter sp.K5869. Hypeptin blocks bacterial cell wall biosynthesis by binding to multiple undecaprenyl pyrophosphate-containing biosynthesis intermediates, forming a stoichiometric 2:1 complex. Hypeptin has antibacterial activity^[1].
Molecular Weight	1022.11
Formula	C₄₄H₇₁N₁₃O₁₅
CAS No.	124883-38-1
Sequence	Ala-{d-Leu}-{d-Arg}-Asn-{d-Asn}-Tyr-Leu-Ile (Lactone bridge:Asn5-Ile8)
Sequence Shortening	A-{d-Leu}-{d-Arg}-N-{d-Asn}-YLI (Lactone bridge:Asn5-Ile8)
SMILES	CC[C@H](C)[C@@H]1NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](CCCNC(N)=N)NC([C@@H](CC(C)C)NC([C@H](C)N)=O)=O)=O)[C@@H](O)C(N)=O)=O)[C@@H](OC1=O)C(N)=O)=O)[C@@H](O)C2=CC=C(C=C2)O)=O)[C@H](O)C(C)C)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Wirtz DA, et al. Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13579-13586. [Content Brief]

Hypeptin Related Classifications

Infection

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hypeptin124883-38-1AntibioticBacterialcell wallcyclodepsipeptideInhibitorinhibitorinhibit

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Hypeptin

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