2. Apoptosis Anti-infection
  3. Apoptosis Fungal Parasite
  4. Hypocrellin B

Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities.

For research use only. We do not sell to patients.

Hypocrellin B Chemical Structure

Hypocrellin B Chemical Structure

CAS No. : 123940-54-5

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Based on 1 publication(s) in Google Scholar

Hypocrellin B Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Hypocrellin B

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].

IC50 & Target

Leishmania

 

Cellular Effect
Cell Line Type Value Description References
BGC-823 IC50
40 nM
Compound: 2
Cytotoxicity against human BGC823 cells assessed as cell death preincubated for 5 hrs in dark condition followed by irradiation with a 532 nm laser of 20 J/cm2 for 1000 seconds measured after 24 hrs by MTT assay
Cytotoxicity against human BGC823 cells assessed as cell death preincubated for 5 hrs in dark condition followed by irradiation with a 532 nm laser of 20 J/cm2 for 1000 seconds measured after 24 hrs by MTT assay
[PMID: 22352922]
In Vitro

Hypocrellin B (2.5 μM, 4 h) induces cell cytotoxicity 24 h after sonodynamic therapy (SDT) in HepG2 cells, and induces induce the early apoptosis[2].
Hypocrellin B shows antifungal and anti-parasite activity against C. albicans and Leishmania donovani respectively (IC50: 5 and 12.7 μg/mL)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hypocrellin B Related Antibodies
In Vivo

Hypocrellin B (2 mg/kg, i.v.) inhibits tumor growth in A549 tumor bearing mice, but the anticancer efficacy is less than hypocrellin B loaded nanoparticles[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

528.51

Formula

C30H24O9
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

CC(C1)=C(C(C)=O)C(C2=C(C3=C(O)C=C4OC)C4=C5C(OC)=CC(O)=C6C5=C2C1=C(OC)C6=O)=C(OC)C3=O
Structure Classification
Initial Source

Hypocrella bambusae, Shiraia bambusicola

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (3.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*Hypocrellin B is usually formulated as a suspension.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8921 mL 9.4606 mL 18.9211 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.61%

SDS (393 KB)

COA (262 KB) HNMR (1269 KB) RP-HPLC (480 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8921 mL 9.4606 mL 18.9211 mL 47.3028 mL
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Hypocrellin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hypocrellin B123940-54-5ApoptosisFungalParasiteAntimicrobialantileishmanialHypocrellinStaphylococcus aureusS. aureusPseudomonas aeruginosaMycobacterium intracellulareInhibitorinhibitorinhibit

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