Hyptadienic acid

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Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID₅₀ value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation.

For research use only. We do not sell to patients.

Hyptadienic acid Chemical Structure

CAS No. : 128397-09-1

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	24.68 μM Compound: 32	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20515057]
HL-60	IC₅₀	15.48 μM Compound: 32	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 20515057]
MCF7	IC₅₀	> 40 μM Compound: 32	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 20515057]
SMMC-7721	IC₅₀	21.01 μM Compound: 32	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 20515057]
SW480	IC₅₀	10.86 μM Compound: 32	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 20515057]

Molecular Weight

470.68

Formula

C₃₀H₄₆O₄

CAS No.

128397-09-1

SMILES

C[C@@]12C([C@@]3([H])[C@](C(O)=O)(CC[C@@H](C)[C@]3(O)C)CC2)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(C(CO)=CC5(C)C)C)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Banno N, et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem. 2004 Jan;68(1):85-90. [Content Brief]