2. Stem Cell/Wnt
  3. β-catenin
  4. I-67

I-67, a structural isomer of I-66 (HY-P10925), is a potent β-catenin inhibitor with an IC50 of <50 nM. I-67 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-67 shows anticancer effects.

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I-67 Chemical Structure

I-67 Chemical Structure

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I-67 Related Antibodies

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Description

I-67, a structural isomer of I-66 (HY-P10925), is a potent β-catenin inhibitor with an IC50 of <50 nM. I-67 can inhibits β-catenin and T-cell factor (TCF) transcription factor interaction. I-67 shows anticancer effects[1].

Molecular Weight

2076.39

Formula

C102H134N18O25S2
Sequence

c-PL3-Asp-Npg-B5-Asp-3COOHF-Aib-Ala-Phe-Lys*3-PyrS2-3Thi-BztA-GlnR*3-Ala-NH2
SMILES

OC(C1=CC(C[C@@H](C(NC(C)(C)C(N[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@@]3(CN(C(OCCC/C=C\CCC[C@@]4(CCC/C=C\C[C@]5(CCCN5C(C)=O)C6=O)NC([C@H](CC(C)(C)C)NC([C@H](CC(O)=O)N6)=O)=O)=O)CC3)C7=O)=O)CCCCNC(CC[C@@H](C(N[C@@H](C)C(N)=O)=O)NC([C@H](CC8=CSC9=C8C=CC=C9)NC([C@H](CC%10=CSC=C%10)N7)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CC(O)=O)NC4=O)=O)=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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I-67 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

I-67I67I 67β-cateninBeta cateninβ-catenin Inhibitorβ-catenin and T-cell factor (TCF) transcription factor interactionanticancer effectsInhibitorinhibitorinhibit

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