1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. I-BOP

I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons.

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I-BOP Chemical Structure

I-BOP Chemical Structure

CAS No. : 128719-90-4

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Description

I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle[1]. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons[2].

In Vitro

I-BOP (1-100 nM) activates the MAP kinase, stimulates the tyrosine phosphorylation, and thus causes the activation of PI3K signaling pathway[1].
I-BOP (0.1-3 μM) enhances the synaptic transmission in hippocampal CA1 neuron at low concentration by increasing the neurotransmitter release, inhibits the excitatory synaptic transmission in hippocampal CA1 neuron through reduction of membrane input resistance at high concentration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: A7r5.HEL.TP cell
Concentration: 1-100 nM
Incubation Time: 24 h
Result: Increased phosphorylated tyrosine.
Molecular Weight

512.38

Formula

C23H29IO5

CAS No.
SMILES

O=C(O)CCC/C=C\C[C@H]1[C@](O2)([H])CC[C@]2([H])[C@@H]1/C=C/[C@@H](O)COC3=CC=C(I)C=C3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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I-BOP
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HY-116431
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