ICI 174864

Cat. No.: HY-101230 Purity: 99.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ICI 174864 is a highly selective, potent δ-receptor antagonist. ICI 174864 is equipotent with naloxone and can not reverse the effect of the μ-agonist [D-Ala2, MePhe4, Gly-Ol5]enkephalin or the κ-agonist-tifluadom.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

ICI 174864 Chemical Structure

CAS No. : 89352-67-0

Size	Price	Stock	Quantity
1 mg	USD 482	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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•Related Screening Libraries:

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View All Opioid Receptor Isoform Specific Products:

View All Isoforms

μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	116 nM Compound: ICI-174864	Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay	[PMID: 26048798]
CHO	IC₅₀	18900 nM Compound: ICI-174864	Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand. Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand.	[PMID: 11052799]
CHO	IC₅₀	703 nM Compound: ICI-174864	Binding affinity was measured in cloned Opioid receptor delta 1 expressed in CHO cells using [3H]- DPDPE as radioligand. Binding affinity was measured in cloned Opioid receptor delta 1 expressed in CHO cells using [3H]- DPDPE as radioligand.	[PMID: 11052799]

Molecular Weight

606.75

Formula

C₃₄H₄₆N₄O₆

CAS No.

89352-67-0

Appearance

Solid

Color

White to off-white

Sequence

{N,N-diallyl}-Tyr-{Aib}-Phe-Leu

Sequence Shortening

{N,N-diallyl}-Y-{Aib}-FL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (164.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6481 mL	8.2406 mL	16.4813 mL
5 mM	0.3296 mL	1.6481 mL	3.2963 mL
10 mM	0.1648 mL	0.8241 mL	1.6481 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB) RP-HPLC (111 KB) MS (206 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. R Cotton, et, al. ICI 174864: a highly selective antagonist for the opioid delta-receptor. Eur J Pharmacol. 1984, 97,3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6481 mL	8.2406 mL	16.4813 mL	41.2031 mL
	5 mM	0.3296 mL	1.6481 mL	3.2963 mL	8.2406 mL
	10 mM	0.1648 mL	0.8241 mL	1.6481 mL	4.1203 mL
	15 mM	0.1099 mL	0.5494 mL	1.0988 mL	2.7469 mL
	20 mM	0.0824 mL	0.4120 mL	0.8241 mL	2.0602 mL
	25 mM	0.0659 mL	0.3296 mL	0.6593 mL	1.6481 mL
	30 mM	0.0549 mL	0.2747 mL	0.5494 mL	1.3734 mL
	40 mM	0.0412 mL	0.2060 mL	0.4120 mL	1.0301 mL
	50 mM	0.0330 mL	0.1648 mL	0.3296 mL	0.8241 mL
	60 mM	0.0275 mL	0.1373 mL	0.2747 mL	0.6867 mL
	80 mM	0.0206 mL	0.1030 mL	0.2060 mL	0.5150 mL
	100 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.4120 mL

ICI 174864 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI 17486489352-67-0ICI174864ICI-174864Opioid Receptorδ-receptor antagonistInhibitorinhibitorinhibit

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