ICT10336

Cat. No.: HY-161838: FAQs
Data Sheet Handling Instructions

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ICT10336 is a hypoxia-responsive prodrug of ATR inhibitor, AZD6738 (HY-19323). ICT10336 is hypoxia-activated and specifically releases AZD6738 only in hypoxic conditions in vitro. This can inhibit ATR activation (T1989 and S428 phosphorylation) and subsequently abrogate HIF1a-mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. ICT10336 is a metabolic substrate of CYPOR activity.

For research use only. We do not sell to patients.

ICT10336 Chemical Structure

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ATM ATR

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Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

ATR

Molecular Weight

708.79

Formula

C₃₂H₄₀N₁₀O₇S

SMILES

C[C@H](COCC1)N1C2=CC(C3(S(=NC([C@H](CC(C)C)NC(OCC4=CN=C([N+]([O-])=O)N4C)=O)=O)(C)=O)CC3)=NC(C5=C6C(NC=C6)=NC=C5)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Francis M Barnieh, et al. Hypoxia-Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment-Resistant Cancer Cells. Adv Sci (Weinh). 2024 Jul 8:e2403831. [Content Brief]

ICT10336 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICT10336ICT 10336ICT-10336ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedProdrughypoxiaT1989S428CYPORInhibitorinhibitorinhibit

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