2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ICT10336

ICT10336 is a hypoxia-responsive prodrug of ATR inhibitor, AZD6738 (HY-19323). ICT10336 is hypoxia-activated and specifically releases AZD6738 only in hypoxic conditions in vitro. This can inhibit ATR activation (T1989 and S428 phosphorylation) and subsequently abrogate HIF1a-mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. ICT10336 is a metabolic substrate of CYPOR activity.

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ICT10336 Chemical Structure

ICT10336 Chemical Structure

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Description

ICT10336 is a hypoxia-responsive prodrug of ATR inhibitor, AZD6738 (HY-19323). ICT10336 is hypoxia-activated and specifically releases AZD6738 only in hypoxic conditions in vitro. This can inhibit ATR activation (T1989 and S428 phosphorylation) and subsequently abrogate HIF1a-mediated adaptation of hypoxic cancers cells, thus selectively inducing cell death in 2D and 3D cancer models. ICT10336 is a metabolic substrate of CYPOR activity.

IC50 & Target[1]

ATR

 

Molecular Weight

708.79

Formula

C32H40N10O7S
SMILES

C[C@H](COCC1)N1C2=CC(C3(S(=NC([C@H](CC(C)C)NC(OCC4=CN=C([N+]([O-])=O)N4C)=O)=O)(C)=O)CC3)=NC(C5=C6C(NC=C6)=NC=C5)=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ICT10336 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICT10336ICT 10336ICT-10336ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedProdrughypoxiaT1989S428CYPORInhibitorinhibitorinhibit

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