2. Neuronal Signaling
  3. Sigma Receptor
  4. (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride  (Synonyms: JO1784)

Cat. No.: HY-108515 Purity: ≥99.0%
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(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ receptor ligand with neuroprotective and anti-amnesic activities.

For research use only. We do not sell to patients.

(+)-Igmesine hydrochloride Chemical Structure

(+)-Igmesine hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 260 In-stock
5 mg USD 630 In-stock
10 mg USD 950 Get quote
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

(+)-Igmesine hydrochloride Related Antibodies

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Description

(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ receptor ligand with neuroprotective and anti-amnesic activities[1].

Molecular Weight

355.94

Formula

C23H30ClN
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.CN(CC1CC1)[C@@](C/C=C/C2=CC=CC=C2)(CC)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 17.79 mg/mL (49.98 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8095 mL 14.0473 mL 28.0946 mL
5 mM 0.5619 mL 2.8095 mL 5.6189 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8095 mL 14.0473 mL 28.0946 mL 70.2366 mL
5 mM 0.5619 mL 2.8095 mL 5.6189 mL 14.0473 mL
10 mM 0.2809 mL 1.4047 mL 2.8095 mL 7.0237 mL
15 mM 0.1873 mL 0.9365 mL 1.8730 mL 4.6824 mL
20 mM 0.1405 mL 0.7024 mL 1.4047 mL 3.5118 mL
25 mM 0.1124 mL 0.5619 mL 1.1238 mL 2.8095 mL
30 mM 0.0936 mL 0.4682 mL 0.9365 mL 2.3412 mL
40 mM 0.0702 mL 0.3512 mL 0.7024 mL 1.7559 mL
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(+)-Igmesine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-IgmesineJO1784JO 1784JO-1784Sigma Receptorcerebral ischaemiagerbil modelneuroprotectiveanti-amnesicInhibitorinhibitorinhibit

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