2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. IIP0943

IIP0943 is a selective inhibitor of PLK1 (polo-like kinase 1), with an IC50 of 5.1 nM for PLK1. In addition, IIP0943 exhibits antiproliferative activity against HCT116 cells, with an IC50 of 0.22 µM. These results suggest that IIP0943 holds promise for research in the field of cancer therapeutics.

For research use only. We do not sell to patients.

IIP0943 Chemical Structure

IIP0943 Chemical Structure

CAS No. : 3040106-93-9

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IIP0943 Related Antibodies

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Description

IIP0943 is a selective inhibitor of PLK1 (polo-like kinase 1), with an IC50 of 5.1 nM for PLK1. In addition, IIP0943 exhibits antiproliferative activity against HCT116 cells, with an IC50 of 0.22 µM. These results suggest that IIP0943 holds promise for research in the field of cancer therapeutics[1].

IC50 & Target

PLK1

5.1 nM (IC50)

Molecular Weight

504.60

Formula

C26H28N6O3S
CAS No.
SMILES

CN1CCN(C2=CC(NC3=NC=C(C)C(OC4=CC=CC5=C4SC(C(N)=O)=C5)=N3)=C(OC)C=C2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IIP0943 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IIP09433040106-93-9IIP 0943IIP-0943Polo-like Kinase (PLK)Inhibitorinhibitorinhibit

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