2. Apoptosis
  3. Apoptosis
  4. Ilicicolin A

Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer.

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Ilicicolin A Chemical Structure

Ilicicolin A Chemical Structure

CAS No. : 22581-06-2

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Ilicicolin A Related Antibodies

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Description

Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer[1].

In Vitro

Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) induces apoptosis in 22Rv1, C4-2B cells[1].
Ilicicolin A (0, 2.5, 5, 10 µM) inhibits cell growth and colony formation in 22Rv1 cells and C4-2B cells in a dose-dependent manner[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the protein expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ilicicolin A Related Antibodies

Cell Viability Assay[1]

Cell Line: 22Rv1, C4-2B cells
Concentration: 0, 2.5, 5, 10 µM
Incubation Time: 96 h
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: 22Rv1, C4-2B cells
Concentration: 0, 2.5, 5, 10 µM
Incubation Time: 48 h
Result: Induced apoptosis and increased the expression of cleaved-PARP1 and cleaved caspase 7.

Western Blot Analysis[1]

Cell Line: 22Rv1, C4-2B cells
Concentration: 0, 2.5, 5, 10 µM
Incubation Time: 48 h
Result: Decreased the expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1.

RT-PCR[1]

Cell Line: 22Rv1, C4-2B cells
Concentration: 0, 2.5, 5, 10 µM
Incubation Time: 48 h
Result: Decreased the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner.
In Vivo

Ilicicolin A (10 mg/kg; i.p.; six times a week for 3 weeks) inhibits tumor growth in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old, 18 g, male NOD/SCID mice (22Rv1 cells) [1]
Dosage: 10 mg/kg
Administration: I.p.; six times a week for 3 weeks
Result: Suppressed tumor growth but did not elicit a significant effect on bodyweight.
Molecular Weight

390.94

Formula

C23H31ClO3
CAS No.
SMILES

O=CC1=C(C(C/C=C(CC/C=C(CC/C=C(C)\C)\C)\C)=C(C(Cl)=C1C)O)O
Structure Classification
Initial Source

Fusarium sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ilicicolin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilicicolin A22581-06-2LL-Z 1272-alphaApoptosisapoptosis22Rv1C4-2B cellsEZH2ARprostate cancerInhibitorinhibitorinhibit

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