Ilmofosine (Synonyms: BM41440)

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Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent.

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Ilmofosine Chemical Structure

CAS No. : 83519-04-4

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References
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Description

Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent^[1]^[2].

In Vitro

Ilmofosine inhibits amastigotes of Leishmania donovani and an antimony-resistant line of L. infantum with ED₅₀ values of 3.73, 3.46 µM^[1].
Ilmofosine (15 µM; 48 h) induces cell cycle arrest at G2 phase in CA46 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[2]

Cell Line:	CA46 cells
Concentration:	15 µM
Incubation Time:	48 h
Result:	Induced cell cycle arrest at G2-phase.

Molecular Weight

525.77

Formula

C₂₆H₅₆NO₅PS

CAS No.

83519-04-4

SMILES

CCCCCCCCCCCCCCCCSCC(COC)COP(OCC[N+](C)(C)C)([O-])=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Croft SL, et al. Antileishmanial activity of the ether phospholipid ilmofosine. Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):217-9. [Content Brief]

[2]. Hofmann J, et al. The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents. Biochem Biophys Res Commun. 1994 Mar 15;199(2):937-43. [Content Brief]

Ilmofosine Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilmofosine83519-04-4BM41440BM 41440BM-41440ParasitePKCProtein kinase CCA46 cellsG2 phaseanti-leishmanialInhibitorinhibitorinhibit

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