ILS-920 

ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12^[1].

ILS-920 promotes neuronal survival and stimulates neurite outgrowth with potent neurotrophic activities in cortical neuronal cultures^[1].
ILS-920 can inhibit L-type Ca²⁺ channels in rat hippocampal neurons and F-11 dorsal root ganglia (DRG)/neuroblastoma cells. ILS-920 can protect neurons from Ca²⁺-induced cell death by modulating Ca²⁺ channels and promote neurite outgrowth via FKBP52 binding^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In a transient middle cerebral artery occlusion (tMCAO) model of ischemic stroke, ILS-920, administered 4 h postocclusion at 10 and 30 mg/kg, significantly reduces infarct volume by 24% and 23% in 72 h, respectively, and robustly enhances functional recovery measured by improvement in neurological deficits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1023.30

C₅₇H₈₆N₂O₁₄

892494-07-4

O[C@H]1[C@H](OC)C[C@H](C[C@@H](C)[C@@H](OC([C@@H]2CCCCN2C(C([C@@]3(O)[C@H](C)CC[C@@H](C[C@H](OC)/C(C)=C/[C@@H]4ON(C5=CC=CC=C5)[C@H]([C@H](C[C@H]6C)C)CC4)O3)=O)=O)=O)CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C6=O)=O)CC1

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ruan B, et al. Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8.  [Content Brief]