2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Imetit dihydrobromide

Imetit dihydrobromide  (Synonyms: VUF 8325 dihydrobromide; SKF 91105 dihydrobromide)

Cat. No.: HY-101173 Purity: ≥98.0%
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Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).

For research use only. We do not sell to patients.

Imetit dihydrobromide Chemical Structure

Imetit dihydrobromide Chemical Structure

CAS No. : 32385-58-3

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5 mg USD 220 In-stock
10 mg USD 375 In-stock
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Based on 1 publication(s) in Google Scholar

Imetit dihydrobromide Related Antibodies

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Description

Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM)[1][2][3].

IC50 & Target[1]

H3 Receptor

0.3 nM (Ki)

H4 receptor

2.7 nM (Ki)

In Vivo

Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[4]
Dosage: 2.5, 5, 10 mg/kg
Administration: i.p. (30 min before Apomorphine)
Result: Reduced the licking response induced by Apomorphine.
Molecular Weight

332.06

Formula

C6H12Br2N4S
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

NC(SCCC1=CN=CN1)=N.Br.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (150.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0115 mL 15.0575 mL 30.1150 mL
5 mM 0.6023 mL 3.0115 mL 6.0230 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.0115 mL 15.0575 mL 30.1150 mL 75.2876 mL
5 mM 0.6023 mL 3.0115 mL 6.0230 mL 15.0575 mL
10 mM 0.3012 mL 1.5058 mL 3.0115 mL 7.5288 mL
15 mM 0.2008 mL 1.0038 mL 2.0077 mL 5.0192 mL
20 mM 0.1506 mL 0.7529 mL 1.5058 mL 3.7644 mL
25 mM 0.1205 mL 0.6023 mL 1.2046 mL 3.0115 mL
30 mM 0.1004 mL 0.5019 mL 1.0038 mL 2.5096 mL
40 mM 0.0753 mL 0.3764 mL 0.7529 mL 1.8822 mL
50 mM 0.0602 mL 0.3012 mL 0.6023 mL 1.5058 mL
60 mM 0.0502 mL 0.2510 mL 0.5019 mL 1.2548 mL
80 mM 0.0376 mL 0.1882 mL 0.3764 mL 0.9411 mL
100 mM 0.0301 mL 0.1506 mL 0.3012 mL 0.7529 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Imetit dihydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imetit dihydrobromide32385-58-3VUF 8325 dihydrobromideSKF 91105 dihydrobromideHistamine ReceptorhistaminemimicsshapechangeeosinophilslickingbehaviorInhibitorinhibitorinhibit

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