2. Immunology/Inflammation
  3. P-selectin
  4. Inclacumab

Inclacumab  (Synonyms: Anti-Human selectin P Recombinant Antibody)

Cat. No.: HY-P99263 Purity: 99.80%
COA

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Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion.

For research use only. We do not sell to patients.

CAS No. : 1256258-86-2

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Inclacumab Related Antibodies

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1 Publications Citing Use of MCE Inclacumab

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Description

Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion[1][2][3].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Inclacumab (0.4-40 μg/mL; 5 min) significantly reduces flow adhesion of P-Selectin with Whole Blood (WB) and isolated White Blood Cell (I-WBC) and shows a more stronger effect on isolated white cells[1].
Inclacumab shows great binding affinity to P-selectin with a Kd value of 9.9 nM[2].
Inclacumab inhibits PSGL-1 mimetic peptide binding with P-selectin with an IC50 value of 1.9 μg/mL[2].
Inclacumab blocks the adhesion of PSGL-1 expressing cells to an immobilized P-selectin with an IC50 value of 430 ng/mL[2].
Inclacumab (0-100 μg/mL; 5min) dose-dependently inhibits thrombin receptor-activating peptide (TRAP)-induced platelet-leukocyte aggregates (PLA) levels with an IC50 value of 1.4 μg/mL[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Inclacumab Related Antibodies
In Vivo

Inclacumab (4 mg/kg; s.c. once) reduces TRAP- and ADP-induced PLA levels in cynomolgus monkeys[3].
Inclacumab (2-50 mg/kg; i.v.; once a week for 13 weeks) inhibits TRAP induced PLA levels in cynomolgus monkeys[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys[3]
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; once
Result: Significantly reduced TRAP-induced PLA levels from 25% to 6% and supressed PLA formation ≥80% for at least 28 days post treatment. Remained plasma concentrations >20 μg/mL during post treatment for 28 days. Significantly inhibited the formation of ADP (10 μM)-induced PLAs.
Animal Model: Cynomolgus monkeys[3]
Dosage: 2, 10, and 50 mg/kg
Administration: Intravenous injection; once daily; for 13 weeks
Result: Inhibited TRAP-induced PLA and remained concentrations at all three dose levels are higher than 20 μg/mL. Persisted the full inhibition of PLA formation between dosing period.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Inclacumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized P-selectin Protein, Human can bind Inclacumab. The EC50 for this effect is 4.28 ng/mL.
Purity & Documentation

Purity: 99.80%

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Inclacumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inclacumab1256258-86-2Anti-Human selectin P Recombinant AntibodyP-selectinCD62humanizedmonoclonalIgG4antibodyPSGL-1cell adhesionI-WBCWBTRAPPLAcynomolgus monkeysInhibitorinhibitorinhibit

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