1. Membrane Transporter/Ion Channel
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  3. Indapamide hemihydrate

Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide hemihydrate is also can reduce left ventricular hypertrophy.

For research use only. We do not sell to patients.

Indapamide hemihydrate Chemical Structure

Indapamide hemihydrate Chemical Structure

CAS No. : 180004-24-4

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Description

Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide hemihydrate is also can reduce left ventricular hypertrophy[1][4].

In Vitro

Indapamide (0.1-500 mg/L; 20min) reduces total insulin secretory response to glucose infusions in isolated perfused rat pancreas[2].
Indapamide (1-100 μM) increases osteoblast proliferation and decreased bone resorption[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Indapamide (1 mg/kg/d; gastric gavage for 8 weeks) lowers blood pressure in spontaneously hypertensive rats (SHRs)[4].
Indapamide (10 mg/kg/d) decreases pressor response to oxotremorine, noradrenaline, and tyramine in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive rats (11 weeks)[4]
Dosage: 1 mg/kg
Administration: Gastric gavage per day for 8 weeks
Result: Decreased blood pressure by 16.9 mm Hg.
Increased the dp/dtmax, ejection fraction (EF) and fractional shortening (FS).
Molecular Weight

749.69

Formula

C16H16ClN3O3S.1/2H2O

CAS No.
SMILES

O=C(NN1C(C)CC2=C1C=CC=C2)C3=CC=C(Cl)C(S(=O)(N)=O)=C3.O.[0.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Indapamide hemihydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Indapamide hemihydrate
Cat. No.:
HY-B0259A
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