2. Anti-infection
  3. Influenza Virus
  4. Influenza virus-IN-3

Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM.

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Influenza virus-IN-3 Chemical Structure

Influenza virus-IN-3 Chemical Structure

CAS No. : 2412451-16-0

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Influenza virus-IN-3 Related Antibodies

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Description

Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM[1].

IC50 & Target

IC50: 0.88 µM (H5N1); 0.10 µM (H5N2); 5.5 µM (H5N6); 0.51 µM (H5N8)[1]
Cellular Effect
Cell Line Type Value Description References
Fibroblast CC50
> 200 μM
Compound: 9a
Cytotoxicity against chicken embryo fibroblast assessed as reduction in cell viability after 48 hrs by CCK8 assay
Cytotoxicity against chicken embryo fibroblast assessed as reduction in cell viability after 48 hrs by CCK8 assay
[PMID: 32092589]
In Vitro

Influenza virus-IN-3 (compound 9a) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 118.17, 1442.6, 34543.33, 78.06, 10206, 0.00048, 0.01222 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza virus-IN-3 Related Antibodies
Molecular Weight

456.60

Formula

C25H32N2O4S
CAS No.
SMILES

O=C(C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](NCC2=CC=C(C3=CSC=C3)C=C2)C1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Influenza virus-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza virus-IN-32412451-16-0Influenza Virusoseltamivir derivativeslow cytotoxicityneuraminidase enzymeantiviralchicken embryo fibroblast cellsInhibitorinhibitorinhibit

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