1. Anti-infection
  2. Influenza Virus
  3. Influenza virus-IN-5

Influenza virus-IN-5 (Compound 5f) is an inhibitor of influenza virus hemagglutinin (HA) with an EC50 of 1 nM against influenza A/H3N2 virus.

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Influenza virus-IN-5 Chemical Structure

Influenza virus-IN-5 Chemical Structure

CAS No. : 2581825-57-0

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Description

Influenza virus-IN-5 (Compound 5f) is an inhibitor of influenza virus hemagglutinin (HA) with an EC50 of 1 nM against influenza A/H3N2 virus[1].

Cellular Effect
Cell Line Type Value Description References
HeLa EC50
> 25 μM
Compound: 5f
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
[PMID: 31753804]
HeLa EC50
≥ 21 μM
Compound: 5f
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
[PMID: 31753804]
HeLa EC50
0.88 μM
Compound: 5f
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
[PMID: 31753804]
MDCK EC50
0.00077 μM
Compound: 5f
Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay
Antiviral activity against IInfluenza A virus H3N2 A/HK/7/87 infected in MDCK cells after 4 days by MTS assay
[PMID: 31753804]
MDCK EC50
0.0012 μM
Compound: 5f
Antiviral activity against Influenza A virus H3N2 A/HK/7/87 infected in MDCK cells assessed as reduction in virus induced cytopathic effect after 4 days by microscopy based method
Antiviral activity against Influenza A virus H3N2 A/HK/7/87 infected in MDCK cells assessed as reduction in virus induced cytopathic effect after 4 days by microscopy based method
[PMID: 31753804]
MDCK CC50
1.5 μM
Compound: 5f
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 4 days by MTS assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability after 4 days by MTS assay
[PMID: 31753804]
Molecular Weight

419.97

Formula

C21H26ClN3O2S

CAS No.
SMILES

O=C(C1=C(C)C2=C(C=CC(Cl)=C2)N1)NN3C(C(C)SC34CCC(CC4)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Influenza virus-IN-5 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Influenza virus-IN-5
Cat. No.:
HY-146147
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