2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. INI-4001

INI-4001 is a TLR7/8 agonist, with EC50 values of 1.89 μM and 4.86 μM for TLR7/8, respectively. INI-4001 induces signaling and SEAP production through TLR7 and TLR8. INI-4001 promotes the generation of high-affinity, specific antibodies against fentanyl, preventing fentanyl from crossing the blood-brain barrier, making it an effective adjuvant for fentanyl vaccines in the opioid use disorder (OUD) population.

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INI-4001 Chemical Structure

INI-4001 Chemical Structure

CAS No. : 2549050-07-7

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INI-4001 Related Antibodies

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Description

INI-4001 is a TLR7/8 agonist, with EC50 values of 1.89 μM and 4.86 μM for TLR7/8, respectively. INI-4001 induces signaling and SEAP production through TLR7 and TLR8. INI-4001 promotes the generation of high-affinity, specific antibodies against fentanyl, preventing fentanyl from crossing the blood-brain barrier, making it an effective adjuvant for fentanyl vaccines in the opioid use disorder (OUD) population[1].
Molecular Weight

1141.50

Formula

C59H109N6O13P
CAS No.
SMILES

OC1=NC2=C(N)N=C(O[C@@H](C)CCC)N=C2N1CC3CCN(CCOP(OCCOCCOCCOC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)(O)=O)CC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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INI-4001 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INI-40012549050-07-7INI4001INI 4001Toll-like Receptor (TLR)TLR7/8SEAPfentanyl resistant vaccineInhibitorinhibitorinhibit

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