2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Insulin degludec

Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Insulin degludec Chemical Structure

Insulin degludec Chemical Structure

CAS No. : 844439-96-9

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Based on 1 publication(s) in Google Scholar

Insulin degludec Related Antibodies

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Description

Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes[1][2].

IC50 & Target

IC50: 19.59 nM/L (insulin receptor)[2]
In Vitro

Insulin degludec (0.001-1000 nM; 12 h) binds with insulin receptor with an IC50 value of 19.59 nM[2].
Insulin degludec (200 nM; 10 min) increases glucose uptake in HL-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Insulin degludec Related Antibodies

Western Blot Analysis[2]

Cell Line: HL-1 cardiomyocytes
Concentration: 200 nM
Incubation Time: 0-60 min
Result: Decreased the level of Akt phosphorylation after 5 and 10 min treatment.
In Vivo

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice with diabetes[1]
Dosage: 5 U/kg
Administration: Subcutaneous injection; 5 U/kg once daily for 30 days
Result: Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

0.1 M HCL : 50 mg/mL (ultrasonic and adjust pH to 2 with 0.1 M HCL)

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.94%

SDS (251 KB)

COA (243 KB) RP-HPLC (200 KB)

Handling Instructions (2659 KB)
References
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Insulin degludec Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Insulin degludec844439-96-9Insulin Receptorcardiac actioninsulin analoguesgluconeogenesisglutamine dipeptideinsulin-induced hypoglycemialiver metabolismtype I diabetesInhibitorinhibitorinhibit

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