Insulin peglispro (Synonyms: BIL)

Cat. No.: HY-P4062: FAQs
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Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins.

For research use only. We do not sell to patients.

Insulin peglispro Chemical Structure

CAS No. : 1200440-65-8

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Description

Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins^[1].

In Vivo

Insulin peglispro (BIL) (s.c., 17, 0.45 or 1.15 mg/kg/d, 52 week) has no effect on Crl:CD(SD) rat survival at any dose, resulting in some increase in body weight. Serum glucose concentrations are unaffected at an administered dose of 0.17 mg/kg, while 0.45 mg/kg shows lower serum glucose concentrations at 3 and 6 hours post-dose on day 1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

8359.32

Formula

C₃₇₀H₅₆₆N₁₀₄O₁₁₀S₄

CAS No.

1200440-65-8

Sequence

Chain1:Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Lys-Pro-Thrchain 2：Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn(Disulfide chain 1 cys7-chain 2 cys7, Disulfide chain 1 cys19-chain 2 cys20, Disulfide chain 2 cys6-cys11)

Sequence Shortening

Chain1:FVNQHLCGSHLVEALYLVCGERGFFYTKPTChain2:GIVEQCCTSICSLYQLENYCN(Disulfide chain 1 cys7-chain 2 cys7, Disulfide chain 1 cys19-chain 2 cys20, Disulfide chain 2 cys6-cys11)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Richard A Byrd, et al. Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs: A Novel, PEGylated Insulin Lispro Analog with a Prolonged Duration of Action. Toxicol Pathol. 2017 Apr;45(3):402-415. [Content Brief]

Insulin peglispro Related Classifications

Metabolic Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Insulin peglispro1200440-65-8BILInsulin ReceptorinsulinglycaemicInhibitorinhibitorinhibit

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