2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. IQTub4P

IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo.

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IQTub4P Chemical Structure

IQTub4P Chemical Structure

CAS No. : 2376321-67-2

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IQTub4P Related Antibodies

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Description

IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo[1].

Cellular Effect
Cell Line Type Value Description References
HeLa EC50
170 nM
Compound: IQTub4P
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by resazurin dye based fluorescence assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by resazurin dye based fluorescence assay
[PMID: 31735573]
HL-60 EC50
570 nM
Compound: IQTub4P
Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth after 24 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth after 24 hrs by MTT assay
[PMID: 31735573]
In Vitro

IQTub4P (48 h) shows strong dose-dependent cytotoxicity in HeLa cells[1].
IQTub4P (0-750 nM, 15 min) shows dose-dependent microtubule network depolymerisation, leads to mitotic arrests and the formation of aberrant multipolar spindles with resulting unstructured chromosome alignment at 120 nM[1].
IQTub4P (0-1.25 μM, 24 h) shows potent induction of G2/M arrest[1].
IQTub4P (10 μM, 2 min) shows potent inhibition of cellular tubulin polymerisation dynamics[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IQTub4P Related Antibodies

Cell Viability Assay

Cell Line: HeLa cells[1]
Concentration:
Incubation Time: 48 h
Result: Showed strong dose-dependent cytotoxicity in HeLa cells, with EC50 of 170 nM, and displayed near-identical cytotoxicity in cell culture as its free phenol form IQTub4 (EC50 = 120 nM).

Cell Cycle Analysis

Cell Line: HeLa cells[1]
Concentration: 0, 0.06, 0.12, 0.5, 0.75, 1.25 μM
Incubation Time: 24 h
Result: Showed potent induction of G2/M arrest, and showed extensive G2/M-arrest from 500 nM.
In Vivo

IQTub4P (Balb/c mice, 25 mg/kg, IP and IV, once every two days, 3 administrations) is well-tolerated in vivo and can avoid short-term cumulative toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice (female)[1]
Dosage: 25 mg/kg
Administration: IP and IV, 3 administration, 48 h intervals
Result: Could avoid short-term cumulative toxicity, and was well-tolerated in vivo, with a single-administration maximal tolerated dose of 32 mg/kg (i.p.) and 50 mg/kg (i.v.).
Molecular Weight

465.30

Formula

C19H18NNa2O8P
CAS No.
SMILES

O=P(O[Na])(O[Na])OC1=CC2=C(C(C3=CC(OC)=C(C(OC)=C3)OC)=NC=C2)C=C1OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IQTub4P Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IQTub4P2376321-67-2Microtubule/TubulinWell-toleratedMicrotubule dynamicsTubulin polymerisationInhibitorinhibitorinhibit

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