IR-251

Cat. No.: HY-155062: FAQs
Data Sheet Handling Instructions

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IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis.

For research use only. We do not sell to patients.

IR-251 Chemical Structure

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250 mg		Get quote
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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description	IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis^[1].
Molecular Weight	886.48
Formula	C₅₁H₇₀BrClN₄O₂
SMILES	CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/CC3N(CCCCCC(O/C(NC4CCCCC4)=N/C5CCCCC5)=O)C(C=CC=C6)=C6C3(C)C)=[N+](CC)C7=C1C=CC=C7.[Br-]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Wang J, et al. A novel multifunctional mitochondrion-targeting NIR fluorophore probe inhibits tumour proliferation and metastasis through the PPAR纬/ROS/尾-catenin pathway. Eur J Med Chem. 2023 Oct 5;258:115435. [Content Brief]

IR-251 Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IR-251IR251IR 251Fluorescent DyeReactive Oxygen SpeciesPPARβ-cateninMitochondrial MetabolismPeroxisome proliferator-activated receptorsBeta cateninAntiproliferativecancerOATPmitochondrionNIRfluorescent probeInhibitorinhibitorinhibit

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IR-251

IR-251 Related Antibodies

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Biological Activity

Purity & Documentation

References

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