Ir-ImNO 

Ir-ImNO is a mitochondria-targeted two-photon probe with excellent cell membrane permeability, capable of detecting both endogenous and exogenous cell membrane permeability. Ir-ImNO can monitor different immune response states of macrophages through various imaging techniques, including one-photon and two-photon phosphorescence imaging as well as phosphorescence lifetime imaging. Ir-ImNO can be utilized in the research to assist in the clinical monitoring of immunotherapy^[1].

Ir-ImNO (5 μM; 6-48 h) exhibits low cytotoxicity in 4T1 and RAW 264.7 cells, maintaining a cell survival rate of over 80% after 48 hours of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

936.52

C₄₉H₃₆ClIrN₆

NC1=C(NCC2=CC=CC=C2)C3=CC=C[N]4=C3C5=C1C=CC=[N]5[Ir+3]67([N]8=C9C(C=CC=C9)=CC=C8C%10=CC=CC=[C-]%107)4[N]%11=C%12C(C=CC=C%12)=CC=C%11C%13=CC=CC=[C-]%136.[Cl-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wen Y, et al. A Mitochondria-Targeted Nitric Oxide Probe for Multimodality Imaging of Macrophage Immune Responses. Anal Chem. 2024;96(17):6666-6673.  [Content Brief]