IRAK4-IN-13

Cat. No.: HY-146111: FAQs
Data Sheet Handling Instructions

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IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC₅₀ of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 µL/min/mg.

For research use only. We do not sell to patients.

IRAK4-IN-13 Chemical Structure

CAS No. : 2667681-57-2

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Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

IRAK4

0.6 nM (IC₅₀)

In Vitro

IRAK4-IN-13 (compound 21) shows cell pIRAK4 potencies with an IC₅₀ of 0.024 µM^[1].
IRAK4-IN-13 (compound 21) shows selectivity with IC₅₀s of 0.0006, 0.002, 0.044, 1.2, 0.018, 0.019, 0.082, 0.036 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

457.53

Formula

C₂₄H₂₇N₉O

CAS No.

2667681-57-2

SMILES

CN1CCC(N2N=CC(NC3=NC(OC4(C)CC4)=C5C(C=CC(C6=CN=CN=C6)=N5)=N3)=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815. [Content Brief]

IRAK4-IN-13 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-132667681-57-2IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinasemetabolic clearanceCaco2 cellsHuman Hepatocytescell pIRAK4Inhibitorinhibitorinhibit

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