IRAK Inhibitors

IRAK4, IC₅₀: .2 nM

IRAK-1

IRAK4, IC₅₀: 57 nM

IRAK4

IRAK1, IC₅₀: 264 nM

IRAK4, IC₅₀: 2500 nM

IRAK1, IC₅₀: 1765 nM

IRAK4, IC₅₀: 128 nM

IRAK-1, IC₅₀: 9 nM

IRAK4, IC₅₀: 3.55 nM

IRAK4, IC₅₀: 21 nM

IRAK1

IRAK1, IC₅₀: 23 nM

IRAK4, IC₅₀: 5 nM

IRAK-1, IC₅₀: 24 nM

IRAK4, IC₅₀: 20 nM

IRAK1, IC₅₀: 72 nM

IRAK4, IC₅₀: 443 nM

IRAK4

IRAK4

IRAK4, IC₅₀: 0.3 nM

IRAK1

IRAK4

IRAK-1, IC₅₀: 167 nM

IRAK1, IC₅₀: 179 nM

hIRAK4, IC₅₀: 6.4 nM
mIRAK4, IC₅₀: 3.5 nM

IRAK4

IRAK4, IC₅₀: 4 μM

IRAK4, IC₅₀: 0.003 μM

IRAK4, IC₅₀: 7.2 μM

IRAK1, IC₅₀: 167 nM

IRAK4, IC₅₀: 3.55 nM

IRAK4

IRAK4, IC₅₀: 57 nM

IRAK4

IRAK4, IC₅₀: 15 nM

IRAK4

IRAK4, IC₅₀: 2.5 ± 0.8 nM

IRAK4, IC₅₀: 1.5 nM

IRAK4, IC₅₀: 1.5 nM

IRAK4, IC₅₀: 0.6 nM

IRAK4, IC₅₀: 4.647 μM (^[1])

IRAK4, IC₅₀: 11.2 nM

IRAK4

IRAK4, DC₅₀: 7 nM

IRAK4, IC₅₀: 0.23 nM

IRAK4

hIRAK4, IC₅₀: 0.6 nM

IRAK-1

IRAK4, DC₅₀: 3 nM

IRAK4, IC₅₀: 5 nM

IRAK4, IC₅₀: 0.002 μM

IRAK4, IC₅₀: 0.015 μM

IRAK4, IC₅₀: 1.3 nM

IRAK4

IRAK4, IC₅₀: .008 μM

IRAK4, IC₅₀: 4.3 nM

IRAK4, IC₅₀: 165 nM (Unphosphorylated inactive IRAK4 )
IRAK4, IC₅₀: 2876 nM (Phosphorylated active IRAK4 )

IRAK4, Ki: 1.4 nM

IRAK4

IRAK4, IC₅₀: 8.7 nM