ISIS 104838 sodium

Cat. No.: HY-145726A Purity: 93.70%: FAQs
Data Sheet SDS COA Handling Instructions

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ISIS 104838 sodium is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.

For research use only. We do not sell to patients.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]rA-T-T-A-G-A-G-A-G-A-G-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rC), sodium salt

ISIS 104838 sodium Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 98	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 254	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 381	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 762	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1220	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1950	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of ISIS 104838 sodium:

ISIS 104838 Get quote
ISIS 104838 triethylamine Get quote

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•Related Small Molecules:

•Related Proteins:

View All TNF Receptor Isoform Specific Products:

View All Isoforms

TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

Biological Activity
Purity & Documentation
References
Customer Review

Description	ISIS 104838 sodium is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis.
Molecular Weight	7743.70
Appearance	Solid
Color	Off-white to light yellow
SMILES	[ISIS 104838 (sodium)]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation	Purity: 93.70% Select Batch: Data Sheet (265 KB) SDS (252 KB) COA (245 KB) LCMS (592 KB) Handling Instructions (2659 KB)
References	[1]. Sewell KL, Geary RS, Baker BF, et al. Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha. J Pharmacol Exp Ther. 2002;303(3):1334-1343. [Content Brief]