Isocucurbitacin D

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Isocucurbitacin D is an antitumor agent.

For research use only. We do not sell to patients.

Isocucurbitacin D Chemical Structure

CAS No. : 68422-20-8

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Biological Activity
Purity & Documentation
References
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Description

Isocucurbitacin D is an antitumor agent^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	13.8 μM Compound: 4	Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay	[PMID: 21459003]
HepG2	IC₅₀	80.33 μM Compound: 4	Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay	[PMID: 21459003]
HSC-T6	EC₅₀	0.06 μM Compound: 4	Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay	[PMID: 21459003]
HSC-T6	IC₅₀	8.7 μM Compound: 4	Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay	[PMID: 21459003]

In Vitro

Isocucurbitacin D inhibits tumor cell growth with ED₅₀s of 0.06, 0.2, 0.6, 0.8 and 1.2 μg/mL against SK-MEL-2, A549, XF498, HCT15 and SK-OV-3 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF-7, MDA MB 231, A2780, A2780 CP, HepG2 and HCT-116 cells
Concentration:	0-100 μM
Incubation Time:	48 h
Result:	Inhibited cell proliferation with IC₅₀s of 12.0, 30.7, 37.8, 47.9, >100 and >100 μM against MDA MB 231, HCT-116, HepG2, MCF-7, A2780 and A2780 CP, respectively.

Molecular Weight

516.67

Formula

C₃₀H₄₄O₇

CAS No.

68422-20-8

SMILES

CC(O)(/C=C/C([C@](O)([C@H]1[C@H](C[C@@]2([C@@]1(CC([C@@]3([C@H]2CC=C4[C@H]3CC([C@H](C4(C)C)O)=O)C)=O)C)C)O)C)=O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ryu S Y, et al. Antitumor activity of Trichosanthes kirilowii. Archives of Pharmacal Research, 1994, 17: 348-353.