Isomaltulose monohydrate 

Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants^[1].

360.31

C₁₂H₂₄O₁₂

58024-13-8

OCC([C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=O.O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lina BA, et al. Isomaltulose (Palatinose): a review of biological and toxicological studies. Food Chem Toxicol. 2002 Oct;40(10):1375-81.  [Content Brief]