2. Anti-infection
  3. HBV
  4. Isothiafludine

Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation.

For research use only. We do not sell to patients.

Isothiafludine Chemical Structure

Isothiafludine Chemical Structure

CAS No. : 960527-22-4

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Based on 1 publication(s) in Google Scholar

Isothiafludine Related Antibodies

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Description

Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 CC50
29 μM
Compound: NZ-4; 10
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay
[PMID: 30594676]
HepG2 2.2.15 IC50
50.4 μM
Compound: NZ-4
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay
[PMID: 27484509]
HepG2 2.2.15 CC50
50.4 μM
Compound: II-8c; NZ-4
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay
[PMID: 32712535]
HepG2 2.2.15 CC50
51.47 μM
Compound: NZ-4
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay
[PMID: 27484509]
HepG2 2.2.15 CC50
59.2 μM
Compound: II-8c; NZ-4
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay
[PMID: 32712535]
In Vitro

Isothiafludine inhibits HBV DNA replication, with an IC50 of 1.33 μM[1].
Isothiafludine (8 days) shows an IC50 (50% cytotoxicity) of 50.4 μM against HepG2.2.15 cells[1].
Isothiafludine (1.25-20 μM, 48 h) also inhibits the replication of 3TC/ETV-dual-resistant and ADV-resistant HBV mutants in virus transfected Huh7 cells[1].
Isothiafludine (10-20 μM, 8 days) decreases the levels of encapsidated HBV pgRNA in HepG2.2.15 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isothiafludine Related Antibodies
In Vivo

Isothiafludine (p.o., 25-100 mg/kg, for 15 days) inhibits DHBV DNA replication in a DHBV-infected duck model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DHBV-infected duck model[2]
Dosage: 25-100 mg/kg
Administration: p.o., for 15 days
Result: Inhibited DHBV DNA in the sera on day 15.
Molecular Weight

375.48

Formula

C18H18FN3OS2
CAS No.
SMILES

O=C(C1=C(CC(C)C)SC(C2=NC=CS2)=N1)NCC3=CC=C(F)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Isothiafludine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isothiafludine960527-22-4NZ-4NZ4NZ 4HBVHepatitis B virusinfectionpgRNAHepG2.2.15Huh7DHBVADV-resistantInhibitorinhibitorinhibit

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