2. Protein Tyrosine Kinase/RTK
  3. Itk
  4. ITK antagonist

ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM.

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ITK antagonist Chemical Structure

ITK antagonist Chemical Structure

CAS No. : 1149753-56-9

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ITK antagonist Related Antibodies

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Description

ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1].

In Vitro

ITK antagonist inhibits DT40 cell (IC50=4 nM) and shows IL-2 inhibition (IC50=20 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ITK antagonist Related Antibodies
Molecular Weight

494.65

Formula

C26H34N6O2S
CAS No.
SMILES

CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ITK antagonist Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITK antagonist1149753-56-9ItkInterleukin-2 inducible T-cell kinaseIL2 inducible T-cell kinaseIRKIL-2IL-4 productionpro-inflammatory cytokinesInhibitorinhibitorinhibit

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ITK antagonist
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