2. Membrane Transporter/Ion Channel
  3. HCN Channel
  4. Ivabradine

Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity.

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Ivabradine Chemical Structure

Ivabradine Chemical Structure

CAS No. : 155974-00-8

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Ivabradine Related Antibodies

Top Publications Citing Use of Products

    Ivabradine purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2019 Feb;234(2):1925-1936.  [Abstract]

    Protein expression levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 are detected by western blotting.

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    Description

    Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].

    In Vivo

    Ivabradine (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice[3].
    Ivabradine (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 25-30 g, 6 weeks male Swiss mice[3]
    Dosage: 1, 10, 20 mg/kg
    Administration: I.p.; for 3 days
    Result: Attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in all brain areas studied, and reduced cleaved caspase-3 expression in the CA1 and DG region of PICRO- and PTZ-treated mice, respectively.
    Animal Model: 3-4 months transgenic (TG) mice with cardiac-restricted overexpression of b2AR[4]
    Dosage: 5, 10, 20 mg/kg
    Administration: P.o; daily for 1 weeks
    Result: Reduced the maximal HR increase in response to the b-agonist isoproterenol, without modifying the response of contractile parameters at 10 mg/kg.
    Clinical Trial
    Molecular Weight

    468.59

    Formula

    C27H36N2O5
    CAS No.
    SMILES

    O=C1N(CCCN(C[C@@H]2C3=CC(OC)=C(OC)C=C3C2)C)CCC4=CC(OC)=C(OC)C=C4C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Ivabradine Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ivabradine155974-00-8HCN ChannelHyperpolarization activated cyclic nucleotide gated channelsorally activeheart rateanticonvulsantanti-ischaemicanti-anginalInhibitorinhibitorinhibit

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