2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. J-115814

J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors.

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J-115814 Chemical Structure

J-115814 Chemical Structure

CAS No. : 329716-61-2

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J-115814 Related Antibodies

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NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

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Description

J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors[1].

IC50 & Target[1]

hY1 receptor

1.4 nM (Ki)

rNPY Y1 receptor

1.8 nM (Ki)

mY1

1.9 nM (Ki)

hY4 receptor

620 nM (Ki)

hY5 receptor

6000 nM (Ki)

human Y2 receptor

>10000 nM (Ki)

mY6

>10000 nM (Ki)

In Vivo

J-115814 (0.3, 1, 3, 10 mg/kg; i.v.) inhibits NPY-induced feeding in SD rats[1].
J-115814 (3, 10, 30 mg/kg; i.p.) shows anorexigenic effect in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: db/db and lean C57BL6 mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: I.p.
Result: Decreasesd nocturnal food intake in a dose-dependent manner.
Animal Model: SD rats[1]
Dosage: 0.3, 1, 3, 10 mg/kg
Administration: I.v.; 1 h before ICV NPY
Result: Inhibited NPY-induced feeding with significant responses at 3 and 10 mg/kg.
Molecular Weight

572.16

Formula

C29H38ClN5O3S
CAS No.
SMILES

CC1=C(SC(CCC2=CC(N3CCOCC3)=CC(NC(C)C4=CC(NC(OC(C)C)=O)=CC(Cl)=C4)=N2)=N1)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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J-115814 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

J-115814329716-61-2J115814J 115814Neuropeptide Y ReceptorNPY receptorneuropeptide YanorexigenicfeedingInhibitorinhibitorinhibit

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