2. Cell Cycle/DNA Damage
  3. CDK
  4. JA397

JA397 is a potent and selective inhibitor for the TAIRE family with cellular activity ranging from IC50 values of 21 nM to 307 nM.

For research use only. We do not sell to patients.

JA397 Chemical Structure

JA397 Chemical Structure

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JA397 Related Antibodies

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

JA397 is a potent and selective inhibitor for the TAIRE family with cellular activity ranging from IC50 values of 21 nM to 307 nM[1].

IC50 & Target

CDK14/Cyclin Y

27.1 nM (EC50)

CDK16/Cyclin Y

39.0 nM (EC50)

Molecular Weight

481.55

Formula

C24H31N7O4
SMILES

O=C(OC(C)(C)C)NC(C=C1)=CC=C1CNC2=NC=CC(NC3=NNC(C(OC(C)(C)C)=O)=C3)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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JA397 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JA397JA 397JA-397CDKCyclin dependent kinaseTAIRECyclin-dependent kinases (CDK14-18)Inhibitorinhibitorinhibit

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HY-160213
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