2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. JAK-IN-27

JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM).

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JAK-IN-27 Chemical Structure

JAK-IN-27 Chemical Structure

CAS No. : 2673176-36-6

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JAK-IN-27 Related Antibodies

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Description

JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].

IC50 & Target

IC50: 3.0 nM (TYK2)、7.7 nM (JAK1)、629.6 nM (JAK3)
Molecular Weight

413.42

Formula

C20H21F2N7O
CAS No.
SMILES

O=C([C@H](C1)C1(F)F)N2[C@H]3CN(C[C@@H]2CC3)C4=NC(C(C=N5)=CN5C)=CN6C4=CC=N6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK-IN-27 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK-IN-272673176-36-6JAKJanus kinaseorally activeJurkat cellsInhibitorinhibitorinhibit

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