2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK STAT
  4. JAK1/STAT3-IN-1

JAK1/STAT3-IN-1 (compound 4f) is an anti-AD (atopic dermatitis) agent by inhibiting JAK1/STAT3 signaling pathway. JAK1/STAT3-IN-1 inhibits NO generation with an IC50 of 2.17 μM. JAK1/STAT3-IN-1 improves the skin condition of AD-like mice, reduces inflammatory infiltration, inhibits the expressions of p-JAK1/JAK1 and p-STAT3/STAT3, and mitigates the excessive immune response on MC903 (Calcipotriol HY-10001)-induced AD-like mice.

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JAK1/STAT3-IN-1 Chemical Structure

JAK1/STAT3-IN-1 Chemical Structure

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JAK1/STAT3-IN-1 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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Description

JAK1/STAT3-IN-1 (compound 4f) is an anti-AD (atopic dermatitis) agent by inhibiting JAK1/STAT3 signaling pathway. JAK1/STAT3-IN-1 inhibits NO generation with an IC50 of 2.17 μM. JAK1/STAT3-IN-1 improves the skin condition of AD-like mice, reduces inflammatory infiltration, inhibits the expressions of p-JAK1/JAK1 and p-STAT3/STAT3, and mitigates the excessive immune response on MC903 (Calcipotriol HY-10001)-induced AD-like mice[1].

IC50 & Target[1]

JAK1

 

STAT3

 

NO production

2.17 μM (IC50)

Molecular Weight

548.67

Formula

C30H33FN4O3S
SMILES

O=C(/C=C/C1=CC=C(N2CCN(C)CC2)C=C1)C3=CC=C(N4CCN(S(C5=CC=C(F)C=C5)(=O)=O)CC4)C=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JAK1/STAT3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK1/STAT3-IN-1JAKSTATJanus kinaseChalcone derivativesAnti-inflammatoryAtopic dermatitisInhibitorinhibitorinhibit

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