JANEX-1 hydrochloride (Synonyms: WHI-P131 hydrochloride; Jak3 inhibitor I hydrochloride)

Cat. No.: HY-138222: FAQs
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JANEX-1 (WHI-P131) hydrochloride is a potent and specific JAK3 inhibitor (K_i=2.3 μM). JANEX-1 hydrochloride shows potent JAK3 inhibitory activity (IC₅₀=78 μM), does not inhibit JAK1 and JAK2.

For research use only. We do not sell to patients.

JANEX-1 hydrochloride Chemical Structure

CAS No. : 188829-39-2

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Other In-stock Forms of JANEX-1 hydrochloride:

JANEX-1

Other Forms of JANEX-1 hydrochloride:

JANEX-1 In-stock

4 Publications Citing Use of MCE JANEX-1 hydrochloride

: JANEX-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2018;14(3):450-464. [Abstract]; Autophagy is induced by IL4 in primary B cells. (A) WT asthma-prone mice were pretreated with the JAK3 inhibitor JANEX-1 before atomized OVAL challenge

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JAK1 JAK2 JAK3 Tyk2 JAK

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

JAK3

78 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	51.472 μM Compound: 5b	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21185195]
HT-29	IC₅₀	92.994 μM Compound: 5b	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 21185195]
SK-OV-3	IC₅₀	74.595 μM Compound: 5b	Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 21185195]

Molecular Weight

333.77

Formula

C₁₆H₁₆ClN₃O₃

CAS No.

188829-39-2

SMILES

COC1=CC2=NC=NC(NC3=CC=C(O)C=C3)=C2C=C1OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. [Content Brief]

[2]. Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23 [Content Brief]

[3]. Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62. [Content Brief]

[4]. Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14(3):450-464. [Content Brief]

JANEX-1 hydrochloride Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JANEX-1188829-39-2WHI-P131Jak3 inhibitor IJANEX1JANEX 1JAKJanus kinaseSpecific inhibitorJAK1JAK2JAK3Inhibitorinhibitorinhibit

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