JCP174 

JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii^[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase^[2][3].

253.68

C₁₂H₁₂ClNO₃

126062-19-9

O=C1OC(OCCC)=C(C2=C1C=C(C=C2)N)Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6.  [Content Brief]

  [2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18.  [Content Brief]

  [3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.  [Content Brief]