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  4. JH-131e-153

JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases.

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JH-131e-153 Chemical Structure

JH-131e-153 Chemical Structure

CAS No. : 742104-91-2

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JH-131e-153 Related Antibodies

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Description

JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1].

IC50 & Target

Munc13-1 C1 domain[1]
In Vitro

Munc13-1 is a target of the diacylglycerol second messenger pathway and plays a role in vesicle maturation during exocytosis. Participates in neurotransmitter release by acting on synaptic vesicle initiation prior to vesicle fusion, and participates in activity-dependent refilling of the easy-release vesicle pool (RRP).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JH-131e-153 Related Antibodies
Molecular Weight

382.53

Formula

C22H38O5
CAS No.
SMILES

CC(C)(C)C(OC[C@@](C/C1=C/CC(CC(C)C)CC(C)C)(CO)OC1=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JH-131e-153 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JH-131e-153742104-91-2OthersMunc13-1Inhibitorinhibitorinhibit

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