2. Anti-infection
  3. Bacterial
  4. JNJ-2901

JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research.

For research use only. We do not sell to patients.

JNJ-2901 Chemical Structure

JNJ-2901 Chemical Structure

CAS No. : 2059985-55-4

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JNJ-2901 Related Antibodies

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Description

JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research[1].

In Vitro

JNJ-2901 (0.005 µM-5 mM, 5 d) inhibits the growth of M. tuberculosis H37Rv-ΔcydAB in 7H9 medium (MIC50: 2.5 nM)[1].
JNJ-2901 inhibits oxygen consumption by the wild-type strain (IC50: 89 nM) and the cytochrome bd knockout strain (ΔcydAB) (IC50: 60 nM) of M. smegmatis, but has no significant effect on the cytochrome bc knockout strain (ΔqcrCAB)[1].
JNJ-2901 inhibits oxygen consumption by M. smegmatis cytochrome bcMtb-like (IC50: 17.4 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-2901 Related Antibodies
In Vivo

JNJ-2901 (10 mg/kg, s.c., 12 d/8 weeks) reduces bacterial load (3.6-log/4.0-log) in 6-8 week old female Balb/cBy mice in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute/chronic mouse model infected with M. tuberculosis H37Rv-ΔcydAB, 6-8 weeks old female Balb/cBy mice[1].
Dosage: 10 mg/kg
Administration: Subcutaneous injection (s.c.), 12 d for acute infection and 8 weeks for chronic infection
Result: Reduced bacterial load in an acute infection model in mice (3.6-log) and in a chronic infection model (4.0-log).
Molecular Weight

540.99

Formula

C24H24ClF3N4O3S
CAS No.
SMILES

CCC1=C(N2C=C(C=CC2=N1)Cl)C(NCC3=CC=C(C=C3)C4CC5(CN(C5)S(=O)(C(F)(F)F)=O)C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-2901 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-29012059985-55-4JNJ2901JNJ 2901BacterialAnti-bacterialM. tuberculosisM. smegmatisM. tuberculosis mouse infection modelTBInhibitorinhibitorinhibit

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