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  4. JNJ-37822681

JNJ-37822681 is a fast dissociating D2 antagonist with activity in inhibiting schizophrenia. JNJ-37822681 has high specificity for D2 receptors and is effective in animal models, inducing increased levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibiting antidepressant activity in the mouse tail suspension test, while having a good brain distribution and lower prolactin release.

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JNJ-37822681 Chemical Structure

JNJ-37822681 Chemical Structure

CAS No. : 935776-74-2

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Description

JNJ-37822681 is a fast dissociating D2 antagonist with activity in inhibiting schizophrenia. JNJ-37822681 has high specificity for D2 receptors and is effective in animal models, inducing increased levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibiting antidepressant activity in the mouse tail suspension test, while having a good brain distribution and lower prolactin release.

Molecular Weight

372.34

Formula

C17H17F5N4
CAS No.
SMILES

FC1=CC=C(CN2CCC(CC2)NC3=NN=C(C(F)(F)F)C=C3)C=C1F
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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JNJ-37822681 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-37822681935776-74-2JNJ37822681JNJ 37822681OthersInhibitorinhibitorinhibit

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