2. GPCR/G Protein
  3. Adenosine Receptor
  4. JNJ-40255293

JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease.

For research use only. We do not sell to patients.

JNJ-40255293 Chemical Structure

JNJ-40255293 Chemical Structure

CAS No. : 1147271-25-7

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JNJ-40255293 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1].

In Vivo

JNJ-40255293 (0.1-10 mg/kg, p.o.) can reverse haloperidol (HY-14538)-induced catalepsy in male Balb/c mice. In male Wistar rats, JNJ-40255293 also dose-dependently reversed haloperidol (0.63 mg/kg, subcutaneous injection)-induced catalepsy, enhanced active arousal, and significantly reversed reserpine (HY-N0480 ) caused deficits in motor activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

402.45

Formula

C23H22N4O3
CAS No.
SMILES

O=C1C2=C(C=C(C=C2)OCCN3CCOCC3)C4=NC(N)=NC(C5=CC=CC=C5)=C41
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-40255293 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-402552931147271-25-7JNJ40255293JNJ 40255293Adenosine ReceptorP1 receptorA2AParkinson's diseaseneurodegenerative diseaseInhibitorinhibitorinhibit

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