2. Apoptosis
  3. Bcl-2 Family
  4. JNJ-4355

JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity.

For research use only. We do not sell to patients.

JNJ-4355 Chemical Structure

JNJ-4355 Chemical Structure

CAS No. : 2697112-33-5

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JNJ-4355 Related Antibodies

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Description

JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity[1][2].

IC50 & Target

Mcl-1

18 pM (Ki)

In Vitro

JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-4355 Related Antibodies
In Vivo

JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

760.32

Formula

C40H43ClFN5O5S
CAS No.
SMILES

CC1=C(C(O)=O)N(CCCOC2=CC3=CC4=C2C=CC(F)=C4)C5=CC=C(Cl)C(C6=C(CSCC7=NN(C)C(CC3)=C7)N(CCOCCOC)N=C6C)=C51
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-4355 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-43552697112-33-5JNJ4355JNJ 4355Bcl-2 FamilyBCL-2MOLP8multiple myelomaInhibitorinhibitorinhibit

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