2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. JNJ-55511118

JNJ-55511118 is a highly potent, reversible, and selective AMPA receptor inhibitor selective for TARP-γ8. JNJ-55511118 fully displaces the radioligand (20 nM) with the Ki of 26 nM in competition binding experiments. JNJ-55511118 is a tool molecule with potential therapeutic utility as an anticonvulsant or neuroprotectant.

For research use only. We do not sell to patients.

JNJ-55511118 Chemical Structure

JNJ-55511118 Chemical Structure

CAS No. : 2036081-86-2

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Description

JNJ-55511118 is a highly potent, reversible, and selective AMPA receptor inhibitor selective for TARP-γ8. JNJ-55511118 fully displaces the radioligand (20 nM) with the Ki of 26 nM in competition binding experiments. JNJ-55511118 is a tool molecule with potential therapeutic utility as an anticonvulsant or neuroprotectant[1].

Molecular Weight

328.67

Formula

C14H8ClF3N2O2
CAS No.
SMILES

O=C1NC2=C(N1)C=C(C3=C(OC(F)(F)F)C=CC=C3Cl)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-55511118 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-555111182036081-86-2JNJ55511118JNJ 55511118iGluRIonotropic glutamate receptorsAMPA receptor modulatorTARP-γ8anticonvulsantneuroprotectanthippocampusInhibitorinhibitorinhibit

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