2. MAPK/ERK Pathway
  3. JNK
  4. JNK3 inhibitor-7

JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

JNK3 inhibitor-7 Chemical Structure

JNK3 inhibitor-7 Chemical Structure

CAS No. : 3034676-52-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

JNK3 inhibitor-7 Related Antibodies

Top Publications Citing Use of Products

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

JNK3 inhibitor-7 is a potent, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 53, 973, 1039 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-7 shows significant neuroprotective effects. JNK3 inhibitor-7 has the potential for the research of Alzheimer’s disease (AD)[1].

IC50 & Target[1]

JNK3

53 nM (IC50)

JNK2

973 nM (IC50)

JNK1

1039 nM (IC50)

In Vitro

JNK3 inhibitor-7 (compound 2h; 20 µM; 24, 48 h) increases primary rat cortex neuron cell viability when treatment with 10 μM amyloid-β1-42[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK3 inhibitor-7 Related Antibodies

Cell Viability Assay[1]

Cell Line: primary rat cortex neuron cells
Concentration: 20 µM
Incubation Time: 24, 48 h
Result: Increased cell viability when treatment with 10 μM amyloid-β1-42.
In Vivo

JNK3 inhibitor-7 (30, 60 mg/kg; p.o.; daily for 4 weeks) shows significant neuroprotective effects in mice[1].
Pharmacokinetic Parameters of JNK3 inhibitor-7 in Sprague-Dawley rats[1].

compound 2h
admin. PO
dose (mg/kg) 3
AUClast (h ng/ml) 350.68
C0 or Cmax (ng/mL) 342.30
Tmax (h) 0.39
T1/2 (h) 0.65
Sprague-Dawley rats, 3 mg/kg p.o.[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7 month-old APP/PS1 AD mice[1]
Dosage: 30, 60 mg/kg
Administration: P.o.; daily for 4 weeks
Result: Decreased the escape time and distance traveled, a dose-dependent increased in the quadrant where the escape zone was located and the time spent.
Molecular Weight

561.63

Formula

C32H31N7O3
CAS No.
SMILES

CNC(OC1=CC=C2N=C(C3=CC4=C(C=CC=C4)C=C3)N(C5=NC(N[C@@H]6CN(CCC6)C(C7CC7)=O)=NC=C5)C2=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

JNK3 inhibitor-7 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK3 inhibitor-73034676-52-0JNKc-Jun N-terminal kinaseorally activecross the blood-brain barrierAlzheimer’s diseaseneuroprotectiveInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
JNK3 inhibitor-7
Cat. No.:
HY-149279
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.