Josamycin hydrochloride (Synonyms: EN-141 hydrochloride)

Cat. No.: HY-B1920A: FAQs
Data Sheet Handling Instructions

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Josamycin (EN-141) hydrochloride is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant K_d from ribosome for Josamycin hydrochloride is 5.5 nM.

For research use only. We do not sell to patients.

Josamycin hydrochloride Chemical Structure

CAS No. : 11033-19-5

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Other In-stock Forms of Josamycin hydrochloride:

Josamycin

Other Forms of Josamycin hydrochloride:

Josamycin In-stock

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Description

IC₅₀ & Target^[1]

Macrolide

Molecular Weight

864.46

Formula

C₄₂H₇₀ClNO₁₅

CAS No.

11033-19-5

SMILES

C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(O1)=O)OC(C)=O)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@](O)([C@H]([C@@H](O3)C)OC(CC(C)C)=O)C)N(C)C)O)CC=O)C)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lovmar M, et al. Kinetics of macrolide action: the Josamycin and erythromycin cases. J Biol Chem. 2004 Dec 17;279(51):53506-15. [Content Brief]

[2]. Osono T, et al. Pharmacokinetics of macrolides, lincosamides and streptogramins. J Antimicrob Chemother. 1985 Jul;16 Suppl A:151-66. [Content Brief]

Josamycin hydrochloride Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Josamycin11033-19-5EN-141EN141EN 141AntibioticBacterialMacrolideantimicrobialpathogensribosomeInhibitorinhibitorinhibit

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