2. Immunology/Inflammation
  3. Interleukin Related
  4. JTE-607 free base

JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base.

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JTE-607 free base Chemical Structure

JTE-607 free base Chemical Structure

CAS No. : 188791-71-1

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Other Forms of JTE-607 free base:

JTE-607 free base Related Antibodies

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Description

JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base[2].

Molecular Weight

524.44

Formula

C25H31Cl2N3O5
CAS No.
SMILES

O=C([C@@H](NC(C1=CC(Cl)=C(C(Cl)=C1O)OCCN2CCN(CC2)C)=O)CC3=CC=CC=C3)OCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JTE-607 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JTE-607188791-71-1JTE607JTE 607Interleukin RelatedILInflammatoryCytokineInhibitorAnti-inflammatoryImmunosuppressionendotoxinTNF-αIL-1βIL-6IL-8IL-10CPSF3inhibitorinhibit

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